2. Signaling Pathways
  3. PROTAC
  4. E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugates

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E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.

E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

E3 Ligase Ligand-Linker Conjugates Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-169395
    (S,R,S)-AHPC-CO-PEG-C2-iodine 3057447-11-4
    (S,R,S)-AHPC-CO-PEG-C2-iodine is an E3 ligase (VHL) ligand-linker conjugate, and can be used for synthesis of PROTACs, such as PROTAC FAK degrader 1 (HY-119932)
    (S,R,S)-AHPC-CO-PEG-C2-iodine
  • HY-163225
    (S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-NH-Boc
    (S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-NH-Boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. (S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-NH-Boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
    (S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-NH-Boc
  • HY-163209
    VH 032 amide-PEG6-amine hydrochloride 2763910-08-1
    VH 032 amide-PEG6-amine hydrochloride (Step 4) is a functionalized von-Hippel-Lindau protein-ligand (VHL) for PROTAC development, consisting of an E3 ligand and a PEG6 ligand. Terminal amines can be coupled to target protein ligands.
    VH 032 amide-PEG6-amine hydrochloride
  • HY-149573
    Thalidomide-4-O-C11-NH2 hydrochloride 99.94%
    Thalidomide-4-O-C11-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-4-O-C11-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.
    Thalidomide-4-O-C11-NH2 hydrochloride
  • HY-173424
    E3 Ligase Ligand-linker Conjugate 178 2768514-43-6
    E3 Ligase Ligand-linker Conjugate 178 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 178 can be used to synthesize MS2133 (HY-173422).
    E3 Ligase Ligand-linker Conjugate 178
  • HY-157753
    E3 Ligase Ligand-linker Conjugate 102
    E3 Ligase Ligand-linker Conjugate 102 is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. E3 Ligase Ligand-linker Conjugate 102 can be used as a key intermediate for the synthesis of complete PROTAC molecules.
    E3 Ligase Ligand-linker Conjugate 102
  • HY-149559
    Thalidomide-5-O-C2-NH2 hydrochloride 2694727-89-2 98.01%
    Thalidomide-5-O-C2-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C2-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.
    Thalidomide-5-O-C2-NH2 hydrochloride
  • HY-42771
    Thalidomide-4-O-CH2-COO(t-Bu) 1950635-36-5 99.26%
    Thalidomide-4-O-CH2-COO(t-Bu) is t-Bu modified Thalidomide (HY-14658), which is the final step intermediate in the synthesis of Thalidomide-4-OH (HY-123096). Thalidomide-4-O-CH2-COO(t-Bu) acts as a Cereblon ligand to recruit CRBN proteins. The t-Bu protecting group at the end of Thalidomide-4-O-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-O-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules.
    Thalidomide-4-O-CH2-COO(t-Bu)
  • HY-161205
    Thalidomide-PIP-(R)C-pyrrolidine-boc 2839668-87-8
    Thalidomide-PIP-(R)C-pyrrolidine-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-PIP-(R)C-pyrrolidine-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
    Thalidomide-PIP-(R)C-pyrrolidine-boc
  • HY-174235
    Thalidomide-OCH2-amide-PEG2-C2-Boc 2827750-18-3
    Thalidomide-OCH2-amide-PEG2-C2-Boc is an E3 ligase ligand-linker conjugate containing a cereblon (CRBN) ligand for E3 ubiquitin ligase and a linker. Thalidomide-OCH2-amide-PEG2-C2-Boc can be used to synthesize PROTAC SARS-CoV-2 Degrader-1 (HY-174233).
    Thalidomide-OCH2-amide-PEG2-C2-Boc
  • HY-156160
    Thalidomide-NH-C10-NH2 hydrochloride 2460022-53-9
    Thalidomide-NH-C10-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-NH-C10-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.
    Thalidomide-NH-C10-NH2 hydrochloride
  • HY-161184
    Deoxy-thalidomide-piperidine-C-piperazine-C2-OH
    Deoxy-thalidomide-piperidine-C-piperazine-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Deoxy-thalidomide-piperidine-C-piperazine-C2-OH can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
    Deoxy-thalidomide-piperidine-C-piperazine-C2-OH
  • HY-W797383
    Phthalimidinoglutarimide-6-piperazine 2229723-92-4
    Phthalimidinoglutarimide-6-piperazine is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.
    Phthalimidinoglutarimide-6-piperazine
  • HY-163224
    (S)-PROTAC PTK6 ligand-O-C2-O-piperidine-Boc
    (S)-PROTAC PTK6 ligand-O-C2-O-piperidine-Boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S)-PROTAC PTK6 ligand-O-C2-O-piperidine-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.
    (S)-PROTAC PTK6 ligand-O-C2-O-piperidine-Boc
  • HY-162189
    E3 Ligase Ligand-linker Conjugate 16
    E3 Ligase Ligand-linker Conjugate 16 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 16 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
    E3 Ligase Ligand-linker Conjugate 16
  • HY-170337
    N-Me-Thalidomide-NH-C6-NH2 2375536-48-2
    N-Me-Thalidomide-NH-C6-NH2 is an E3 ligase ligand-linker conjugate. N-Me-Thalidomide-NH-C6-NH2 can be used to synthesize Anti-inflammatory agent 70 (HY-157570).
    N-Me-Thalidomide-NH-C6-NH2
  • HY-138851
    Thalidomide-NH-amido-C5-NH2 2763827-12-7
    Thalidomide-NH-amido-C5-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
    Thalidomide-NH-amido-C5-NH2
  • HY-176517
    (R,S,S)-VH032-Me-glycine 2407458-67-5
    (R,S,S)-VH032-Me-glycine is an E3 ligase ligand-linker conjugate. (R,S,S)-VH032-Me-glycine can be used to synthesize XF067-68 (HY-150403).
    (R,S,S)-VH032-Me-glycine
  • HY-178827
    Thalidomide-NH-C4 1809556-65-7
    Thalidomide-NH-C4 is an E3 ligase ligand-linker conjugate containing a CRBN ligand and a linker. Thalidomide-NH-C4 can bind to a target protein ligand to form a PROTAC molecule, LD-110 (HY-178825).
    Thalidomide-NH-C4
  • HY-W584514
    Thalidomide-NH-(CH2)2-NH2 TFA 1957235-67-4
    Thalidomide-NH-(CH2)2-NH2 TFA is an alkyl-modified Thalidomide (HY-14658) that acts as a Cereblon ligand to recruit CRBN proteins. Thalidomide-NH-(CH2)2-NH2 TFA is a key intermediate in the synthesis of CRBN-based PROTAC molecules designed to synthesize small PROTAC molecules targeting SHP2 protein.
    Thalidomide-NH-(CH2)2-NH2 TFA
Cat. No. Product Name / Synonyms Application Reactivity
E3 Ligase Ligand-Linker Conjugates Isoform Comparison

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